Lipocalin-2 is involved in emotional behaviors and cognitive function

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Lipocalin-2 is involved in emotional behaviors and cognitive function

Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cogniti...

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ژورنال

عنوان ژورنال: Frontiers in Cellular Neuroscience

سال: 2013

ISSN: 1662-5102

DOI: 10.3389/fncel.2013.00122